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Registros recuperados: 37
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A comparison of public and private obstructive sleep apnea clinics BJMBR
Zonato,A.I.; Bittencourt,L.R.; Martinho,F.L.; Baiard,P.; Togeiro,S.M.; Benedito-Silva,A.A.; Tufik,S..
The aim of the present study was to compare the clinical findings and polysomnography results obtained at public and private clinics in Brazil, the follow-up after diagnosis, and the therapeutic aspects related to continuous positive airway pressure. Patients who snore and who have obstructive sleep apnea were retrospectively divided into two groups, i.e., public clinic (N = 307) and private clinic (N = 317). Data concerning age, sex, body mass index (BMI), neck circumference, medical history, sleepiness scale, follow-up after diagnosis, and acceptance of continuous positive airway pressure therapy were collected. Mean age was 50 ± 12 (range: 15-80) for public patients and 48 ± 12 years (range: 19-91) for private patients. Mean BMI was 30 ± 6 (range:...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Obstructive sleep apnea; Social class aspects; Anthropometric aspects; Continuous positive airway pressure.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000100010
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A link between sleep loss, glucose metabolism and adipokines BJMBR
Padilha,H.G.; Crispim,C.A.; Zimberg,I.Z.; De-Souza,D.A.; Waterhouse,J.; Tufik,S.; de-Mello,M.T.
The present review evaluates the role of sleep and its alteration in triggering problems of glucose metabolism and the possible involvement of adipokines in this process. A reduction in the amount of time spent sleeping has become an endemic condition in modern society, and a search of the current literature has found important associations between sleep loss and alterations of nutritional and metabolic contexts. Studies suggest that sleep loss is associated with problems in glucose metabolism and a higher risk for the development of insulin resistance and type 2 diabetes mellitus. The mechanism involved may be associated with the decreased efficacy of regulation of the hypothalamus-pituitary-adrenal axis by negative feedback mechanisms in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Glucose metabolism; Insulin resistance; Sleep loss; Adipokines; Type 2 diabetes mellitus; Inflammatory status.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001000003
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Assessment of ventilatory neuromuscular drive in patients with obstructive sleep apnea BJMBR
Bittencourt,L.R.A.; Moura,S.M.T.; Bagnato,M.C.; Gregório,L.C.; Tufik,S.; Nery,L.E..
The presence of abnormalities of the respiratory center in obstructive sleep apnea (OSA) patients and their correlation with polysomnographic data are still a matter of controversy. Moderately obese, sleep-deprived OSA patients presenting daytime hypersomnolence, with normocapnia and no clinical or spirometric evidence of pulmonary disease, were selected. We assessed the ventilatory control and correlated it with polysomnographic data. Ventilatory neuromuscular drive was evaluated in these patients by measuring the ventilatory response (VE), the inspiratory occlusion pressure (P.1) and the ventilatory pattern (VT/TI, TI/TTOT) at rest and during submaximal exercise, breathing room air. These analyses were also performed after inhalation of a hypercapnic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ventilatory neuromuscular drive; Sleep apnea; Polysomnography; Ventilatory control.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000400005
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Catecholamine response to exercise in individuals with different levels of paraplegia BJMBR
Steinberg,L.L.; Lauro,F.A.A.; Sposito,M.M.M.; Tufik,S.; Mello,M.T.; Naffah-Mazzacoratti,M.G.; Cavalheiro,E.A.; Silva,A.C..
The purpose of this study was to investigate the effect of the level of injury on the serum level of norepinephrine (Nor) and epinephrine (Epi) at rest and after maximal exercise in individuals with paraplegia. Twenty-six male spinal cord-injured subjects with complete paraplegia for at least 9 months were divided into two groups of 13 subjects each according to the level of injury, i.e., T1-T6 and T7-T12. Serum Nor and Epi concentrations were measured by HPLC-ECD, at rest (PRE) and immediately after a maximal ergospirometric test (POST). Statistical analysis was performed using parametric and non-parametric tests. Maximal heart rate, peak oxygen uptake, and PRE and POST Nor were lower in the T1-T6 than in the T7-T12 group (166 ± 28 vs 188 ± 10 bpm; 18.0 ±...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Catecholamines; Paraplegia; Exercise; Norepinephrine; Epinephrine; Spinal cord injury.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000800007
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Comparison of AutoSetä and polysomnography for the detection of apnea-hypopnea events BJMBR
Bagnato,M.C.; Nery,L.E.; Moura,S.M.T.; Bittencourt,L.R.A.; Tufik,S..
The use of the flow vs time relationship obtained with the nasal prongs of the AutoSetä (AS) system (diagnosis mode) has been proposed to detect apneas and hypopneas in patients with reasonable nasal patency. Our aim was to compare the accuracy of AS to that of a computerized polysomnographic (PSG) system. The study was conducted on 56 individuals (45 men) with clinical characteristics of obstructive sleep apnea (OSA). Their mean (± SD) age was 44.6 ± 12 years and their body mass index was 31.3 ± 7 kg/m2. Data were submitted to parametric analysis to determine the agreement between methods and the intraclass correlation coefficient was calculated. The Student t-test and Bland and Altman plots were also used. Twelve patients had an apnea-hypopnea index...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Obstructive sleep apnea; Polysomnography; Computerized diagnostic system.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000500005
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Delta sleep instability in children with chronic arthritis BJMBR
Lopes,M.C.; Guilleminault,C.; Rosa,A.; Passarelli,C.; Roizenblatt,S.; Tufik,S..
The objective of the present study was to evaluate the expression of a cyclic alternating pattern (CAP) in slow wave sleep (SWS) in children with the well-defined chronic syndrome juvenile idiopathic arthritis (JIA). Twelve patients (9-17 years of age), 7 girls, with JIA were compared to matched controls by age, pubertal stage and gender. After one night of habituation in the sleep laboratory, sleep measurements were obtained by standard polysomnography with conventional sleep scoring and additional CAP analyses. The sleep parameters of the JIA and control groups were similar for sleep efficiency (91.1 ± 6.7 vs 95.8 ± 4.0), sleep stage in minutes: stage 1 (16.8 ± 8.5 vs 17.8 ± 4.0), stage 2 (251.9 ± 41 vs 262.8 ± 38.1), stage 3 (17.0 ± 6.0 vs 15.1 ± 5.7),...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Children; Chronic-arthritis; Cyclic alternating pattern; Sleep fragmentation.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001000018
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Different stress modalities result in distinct steroid hormone responses by male rats BJMBR
Andersen,M.L.; Bignotto,M.; Machado,R.B.; Tufik,S..
Since both paradoxical sleep deprivation (PSD) and stress alter male reproductive function, the purpose of the present study was to examine the influence of PSD and other stressors (restraint, electrical footshock, cold and forced swimming, N = 10 per group) on steroid hormones in adult Wistar male rats. Rats were submitted to chronic stress for four days. The stressors (footshock, cold and forced swimming) were applied twice a day, for periods of 1 h at 9:00 and 16:00 h. Restrained animals were maintained in plastic cylinders for 22 h/day whereas PSD was continuous. Hormone determination was measured by chemiluminescent enzyme immunoassay (testosterone), competitive immunoassay (progesterone) and by radioimmunoassay (corticosterone, estradiol, estrone)....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Paradoxical sleep deprivation; Stress; Testosterone; Progesterone; Estrogen; Corticosterone.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000600003
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Do Caucasian and Asian clocks tick differently? BJMBR
Barbosa,A.A.; Pedrazzoli,M.; Koike,B.D.V.; Tufik,S..
The Period 3 and Clock genes are important components of the mammalian molecular circadian system. Studies have shown association between polymorphisms in these clock genes and circadian phenotypes in different populations. Nevertheless, differences in the pattern of allele frequency and genotyping distribution are systematically observed in studies with different ethnic groups. To investigate and compare the pattern of distribution in a sample of Asian and Caucasian populations living in Brazil, we evaluated two well-studied polymorphisms in the clock genes: a variable number of tandem repeats (VNTR) in PER3 and a single nucleotide polymorphism (SNP) in CLOCK. The aim of this investigation was to search for clues about human evolutionary processes related...
Tipo: Info:eu-repo/semantics/other Palavras-chave: PER3 gene; CLOCK gene; Circadian rhythms; Asian; Caucasian; Ethnic.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000100013
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Effect of sildenafil (Viagra®) on the genital reflexes of paradoxical sleep-deprived male rats BJMBR
Andersen,M.L.; Bignotto,M.; Tufik,S..
Since there is evidence that paradoxical sleep deprivation (PSD) elicits penile erection (PE) and ejaculation (EJ), and that the erectile response of rats is mediated by nitric oxide, the present study sought to extend the latter finding by assessing the effects of sildenafil on the genital reflexes of male Wistar rats subjected to PSD. We also determined the influence of sildenafil on hormone concentrations. In the first experiment, sildenafil at doses ranging from 0.08 to 0.32 mg/kg was administered intraperitoneally to rats that had been deprived of sleep for 4 days and to home cage controls (N = 8-10/group). The frequency of PE and EJ was measured for 60 min. PSD alone induced PE in 50% of the animals; however, a single injection of sildenafil did not...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Paradoxical sleep deprivation; Sildenafil; Genital reflexes; Dopamine; Testosterone; Progesterone.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100008
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Effect of smoking habits on sleep BJMBR
Conway,S.G.; Roizenblatt,S.S.; Palombini,L.; Castro,L.S.; Bittencourt,L.R.A.; Silva,R.S.; Tufik,S..
To evaluate the effect of smoking habits on sleep, data from 1492 adults referred to the Sleep Institute were accessed and divided into 3 categories of smoking status: current, former and non-smokers. Categories of pack-years (<15 and ≥15) defined smoking severity. The association of smoking status and smoking severity with sleep was analyzed for sleep parameters, especially apnea and hypopnea index (AHI) ≥5, more than 5% of total sleep time (TST) spent with oxyhemoglobin saturation (SaO2) <90%, and arousal index. The arousal index was higher among current (21 ± 17) and former smokers (20 ± 17) than non-smokers (17 ± 15; P < 0.04). Former smokers had a higher percent of TST at SaO2 <90% than non-smokers (9 ± 18 vs 6 ± 13; P < 0.04). Former...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Smoking; Tobacco; Smoking cessation; Sleep; Sleep-disordered breathing.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000800014
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Effects of a physical fitness program on memory and blood viscosity in sedentary elderly men BJMBR
Antunes,H.K.; De Mello,M.T.; Santos-Galduróz,R.F.; Galduróz,J.C.F.; Lemos,V.Aquino; Tufik,S.; Bueno,O.F.A..
The aim of this study was to investigate the effects of a 6-month exercise program on cognitive function and blood viscosity in sedentary elderly men. Forty-six healthy inactive men, aged 60–75 years were randomly distributed into a control group (n=23) and an experimental group (n=23). Participants underwent blood analysis and physical and memory evaluation, before and after the 6-month program of physical exercise. The control group was instructed not to alter its everyday activities; the experimental group took part in the fitness program. The program was conducted using a cycle ergometer, 3 times per week on alternate days, with intensity and volume individualized at ventilatory threshold 1. Sessions were continuous and maximum duration was 60 min...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cognition; Elderly adults; Physical exercise.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000900805
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Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study BJMBR
Santos-Galduróz,R.F.; Galduróz,J.C.F.; Facco,R.L.; Hachul,H.; Tufik,S..
Hormone decline is common to all women during aging and, associated with other factors, leads to cognitive impairment. Its replacement enhances cognitive performance, but not all women present a clinical and family or personal history that justifies its use, mainly women with a history of cancer. The aim of this study was to determine whether a daily oral dose of 80 mg of isoflavone extract for 4 months can produce benefits in women with low hormone levels, contributing to improvement in cognitive aspects. The sample comprised 50- to 65-year-old women whose menstruation had ceased at least 1 year before and who had not undergone hormone replacement. The volunteers were allocated to two groups of 19 individuals each, i.e., isoflavone and placebo. There was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Isoflavone; Cognitive disorders; Aging; Information integration; Memory; Menopause.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100016
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Effects of type of physical exercise and leisure activities on the depression scores of obese Brazilian adolescent girls BJMBR
Stella,S.G.; Vilar,A.P.; Lacroix,C.; Fisberg,M.; Santos,R.F.; Mello,M.T.; Tufik,S..
Several studies have indicated that depressive states may lead to hypokinesia with diminished metabolic rate and energy use. Hypokinesia associated with certain eating behaviors may lead to an unfavorable energy balance that can contribute to the emergence and prevalence of obesity among children and adults. The purpose of the present study was to examine the possibility of reducing depression inventory scores in female adolescents with third-degree obesity while testing the effectiveness of different exercise programs in reducing anxiety and depression scores. The sample consisted of 40 female subjects (mean age 16 ± 1.56 years) divided into 4 groups (aerobic training, anaerobic training, leisure activities, and control). Subjects had a body mass index of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Adolescents; Physical exercise; Leisure activity; Obesity.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001100017
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Effects on prolactin secretion and binding to dopaminergic receptors in sleep-deprived lupus-prone mice BJMBR
Palma,B.D.; Hipolide,D.C.; Tufik,S..
Sleep disturbances have far-reaching effects on the neuroendocrine and immune systems and may be linked to disease manifestation. Sleep deprivation can accelerate the onset of lupus in NZB/NZWF1 mice, an animal model of severe systemic lupus erythematosus. High prolactin (PRL) concentrations are involved in the pathogenesis of systemic lupus erythematosus in human beings, as well as in NZB/NZWF1 mice. We hypothesized that PRL could be involved in the earlier onset of the disease in sleep-deprived NZB/NZWF1 mice. We also investigated its binding to dopaminergic receptors, since PRL secretion is mainly controlled by dopamine. Female NZB/NZWF1 mice aged 9 weeks were deprived of sleep using the multiple platform method. Blood samples were taken for the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Systemic lupus erythematosus; NZB/NZWF1 mice; Prolactin; Stress; Autoradiography; Dopamine transporter.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000300012
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Gastroesophageal reflux episodes in asthmatic patients and their temporal relation with sleep architecture BJMBR
Mello-Fujita,L.; Roizenblat,S.; Frison.,C.R.; Rodrigues Junior,L.; Garbuio,S.; Tufik,S.; Bittencourt,L.R.A..
Gastroesophageal reflux (GER) is common in asthma patients and can contribute to sleep disruption. The aim of the present study was to determine the time-related distribution of GER events together with their impact on sleep in asthmatic subjects with GER disease symptoms. The inclusion criteria were: 18-65 years, controlled moderate to severe asthma and GER-compatible clinical evidence. The exclusion criteria were: chronic obstructive lung disease, smoking, infections of the upper airways, use of oral corticosteroids, other co-morbidities, pregnancy, sleep-related disorders, night-time shift work, and the use of substances with impact on sleep. Asthmatic patients with nocturnal symptoms were excluded. All-night polysomnography and esophageal pH monitoring...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Gastroesophageal reflux; Polysomnography; Sleep.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200012
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Gender and age differences in polysomnography findings and sleep complaints of patients referred to a sleep laboratory BJMBR
Silva,A.; Andersen,M.L.; De Mello,M.T.; Bittencourt,L.R.A.; Peruzzo,D.; Tufik,S..
Our objective was to examine the effet of gender on the sleep pattern of patients referred to a sleep laboratory. The data (questionnaires and polysomnographic recordings) were collected from a total of 2365 patients (1550 men and 815 women). The polysomnography permits an objective assessment of the sleep pattern. We included only polysomnography exams obtained with no more than one recording system in order to permit normalization of the data. Men had a significantly higher body mass index than women (28.5 ± 4.8 vs 27.7 ± 6.35 kg/m²) and had a significantly higher score on the Epworth Sleepiness Scale (10.8 ± 5.3 vs 9.5 ± 6.0), suggesting daytime sleepiness. Women had a significantly higher sleep latency than men, as well as a higher rapid eye movement...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sleep; Gender; Polysomnography; Apnea; Insomnia; Database.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001200005
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Gentle handling temporarily increases c-Fos in the substantia nigra pars compacta BJMBR
Santos,C.A.; Andersen,M.L.; Lima,M.M.S.; Tufik,S..
Dopaminergic neurotransmission is involved in the regulation of sleep. In particular, the nigrostriatal pathway is an important center of sleep regulation. We hypothesized that dopaminergic neurons located in substantia nigra pars compacta (SNpc) could be activated by gentle handling, a method to obtain sleep deprivation (SD). Adult male C57/BL6J mice (N = 5/group) were distributed into non-SD (NSD) or SD groups. SD animals were subjected to SD once for 1 or 3 h by gentle handling. Two experiments were performed. The first determined the activation of SNpc neurons after SD, and the second examined the same parameters after pharmacologically induced dopaminergic depletion using intraperitoneal reserpine (2 mg/kg). After 1 or 3 h, SD and NSD mice were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sleep deprivation; Dopamine; C-Fos; Substantia nigra pars compacta; Gentle handling of mice.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001000015
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Neuroethologic differences in sleep deprivation induced by the single- and multiple-platform methods BJMBR
Medeiros,R.; Lenneberg-Hoshino,C.; Hoshino,K.; Tufik,S..
It has been proposed that the multiple-platform method (MP) for desynchronized sleep (DS) deprivation eliminates the stress induced by social isolation and by the restriction of locomotion in the single-platform (SP) method. MP, however, induces a higher increase in plasma corticosterone and ACTH levels than SP. Since deprivation is of heuristic value to identify the functional role of this state of sleep, the objective of the present study was to determine the behavioral differences exhibited by rats during sleep deprivation induced by these two methods. All behavioral patterns exhibited by a group of 7 albino male Wistar rats submitted to 4 days of sleep deprivation by the MP method (15 platforms, spaced 150 mm apart) and by 7 other rats submitted to...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Sleep deprivation methods; Stress; Social interactions; Group crowding effects.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000500012
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Obese obstructive sleep apnea patients with tonsil hypertrophy submitted to tonsillectomy BJMBR
Martinho,F.L.; Zonato,A.I.; Bittencourt,L.R.A.; Soares,M.C.M.; Silva,R.F.N.; Gregório,L.C.; Tufik,S..
The physiopathology of obstructive sleep apnea-hypopnea syndrome (OSAHS) is multifactorial and obesity has been shown to be one of the main factors correlated with its occurrence. In obese patients with anatomical alterations of the upper airways it is often difficult to predict success for surgical correction since obesity is a limiting factor. Therefore, the aim of the present study was to evaluate the results of tonsillectomy in a specific group of patients, i.e., obese OSAHS patients with tonsil hypertrophy. Seven OSAHS patients with moderate obesity with obstructive palatine tonsil hypertrophy were submitted to tonsillectomy. All patients were submitted to pre- and postoperative appraisal of body mass index, otorhinolaryngology examination and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sleep apnea syndrome; Obesity; Surgery; Tonsillectomy; Apnea and hypopnea index.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000800017
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Pain-related diseases and sleep disorders BJMBR
Roizenblatt,M.; Rosa Neto,N.S.; Tufik,S.; Roizenblatt,S..
Pain and sleep share mutual relations under the influence of cognitive and neuroendocrine changes. Sleep is an important homeostatic feature and, when impaired, contributes to the development or worsening of pain-related diseases. The aim of the present review is to provide a panoramic view for the generalist physician on sleep disorders that occur in pain-related diseases within the field of Internal Medicine, such as rheumatic diseases, acute coronary syndrome, digestive diseases, cancer, and headache.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sleep disorders; Rheumatic diseases; Acute coronary syndrome; Irritable bowel syndrome; Cancer; Headache.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000900001
Registros recuperados: 37
Primeira ... 12 ... Última
 

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